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KMID : 0387420130240030263
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Korean Society of Oriental Neuropsychiatry
2013 Volume.24 No. 3 p.263 ~ p.270
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Effects of Galgunhaejutang on Alcohol Consumption in C57BL/6 Mice
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Cho Seung-Hun
Kim Hyeun-Kyeung
Kim Jong-Woo
Kim Sung-Gon
Whang Wei-Wan
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Abstract
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Objectives: Galgunhaejutang extract (GHT) is a Traditional Korean medical herbal mixture that has been tradtionally used to treat alcohol consumption. This study was preformed to evaluate the effects of GHT on alcohol consumption in C57BL/6 mice.
Methods: Sixty three C57BL/6 mice were alcohol dependence-induced by limited access paradigm. Water, GHT 0.688 g/kg (GHT-L), or GHT 3.45 g/kg (GHT-H) were administrated for 10 days. The amounts of alcohol consumption for 2 hours, water consumption for 22 hours, food intake for 24 hours and body weight were measured.
Results: There weren’t significant differences in 2 hours of alcohol consumption, 22 hours of water consumption, 24 hours of food intake and body weight for ten days between vehicle group and GHT-L or GHT-H group.
Conclusions: Further studies employing multi-dose and long term administration of GHT (more than 10 days) might be of benefit.
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KEYWORD
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Korean traditional medicine, Herbal mixture, Alcohol consumption, C57BL/6
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